Publications
Seven-up acts in neuroblasts to specify adult central complex neuron identity and initiate neuroblast decommissioning
Dillon NR, Manning L, Hirono K, Doe CQ (2024)
Development 151 (3), https://doi.org/10.1242/dev.202504
Notch signaling and Bsh homeodomain activity are integrated to diversify Drosophila lamina neuron types
Xu C, Ramos TB, Marshall O, Doe CQ (2024)
eLife January https://doi.org/10.7554/eLife.90136.3
Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity
Xu C, Ramos TB, Rogers EM, Reiser MB, Doe CQ (2023)
eLife December https://doi.org/10.7554/eLife.90133.3
Imp is expressed in INPs and newborn neurons where it regulates neuropil targeting in the central complex
Munroe JA, Doe CQ (2023)
Neural Development, PMCID: PMC10685609, doi: 10.1186/s13064-023-00177-9
From temporal patterning to neuronal connectivity in Drosophila type I neuroblast lineages
Pollington HQ, Seroka AQ, Doe CQ (2023)
Seminars in Cell and Developmental Biology, 142 4-12, https://doi.org/10.1016/j.semcdb.2022.05.022
Developmental origin of the Pair1 descending interneuron
Linskens A, Doe CQ, Lee K (2022)
microPublicationBiology, PMID 36606082 DOI: 10.17912/micropub.biology.000707
Imp is required for timely exit from quiescence in Drosophila type II neuroblasts
Munroe J, Syed MH, Doe CQ (2022)
PLoS One, Dec 15:17(12), https://doi.org/10.1371/journal.pone.0272177
Presynaptic contact and activity opposingly regulate postsynaptic dendrite outgrowth
Heckman EL, Doe CQ (2022)
eLife November, doi.org/10.7554/eLife.82093, PMCID: PMC728994
Single cell RNA-seq analysis reveals temporally-regulated and quiescence-regulated gene expression in Drosophila larval neuroblasts
Dillon N, Cocanougher B, Sood C, Yuan X, Kohn AB, Moroz LL, Siegrist SE, Zlatic M, Doe CQ (2022)
Neural Development Aug 24; 17(1):7. doi: 10.1186/s13064-022-00163-7, PMID: 36002894
Transcriptional profiling from whole embryos to single neuroblast lineages in Drosophila
Seroka A, Lai SL, Doe CQ (2022)
Developmental Biology 489, 21-33. doi.org/10.1016/j.ydbio.2022.05.018
Hunchback activates Bicoid in Pair1 neurons to regulate synapse number and locomotor circuit function
Lee KM, Linskens AM, Doe CQ (2022)
Current Biology Apr 29; S0960-9822(22)00594-2. doi: 10.1016/j.cub.2022.04.025, PMCID: PMC9178783
Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity
Xu C, Ramos TB, Rogers EM, Reiser MB, Doe CQ (2021)
bioRxiv doi: https://doi.org/10.1101/2021.10.01.462699
Mechanosensory input during circuit formation shapes Drosophila motor behavior through patterned spontaneous network activity
Carreira-Rosario A, York RA, Choi M, Doe CQ, Clandinin TR (2021)
Current Biology 31, 1-9, November, doi.org/10.1016/j.cub.2021.08.022, PMCID: PMC8665011
A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila
Lee K, Doe CQ (2021)
eLife July, DOI: https://doi.org/10.7554/eLife.69767, PMCID: PMC8298091
A developmental framework linking neurogenesis and circuit formation in the Drosophila CNS
Mark B, Lai S-L, Zarin AA, Manning L, Pollington HQ, Litwin-Kumar A, Cardona A, Truman JW, Doe CQ (2021)
eLife May 2021, doi.org/10.7554/eLife.67510, PMCID: PMC8139831
A locomotor neural circuit persists and functions similarly in larvae and adult Drosophila
Lee K, Doe CQ (2021)
bioRxiv, April, doi.org/10.1101/2021.04.27.441684
Astrocytes close a motor circuit critical period
Ackerman SD, Perez-Catalan NA, Freeman MR, Doe CQ (2021)
Nature 592, 414–420(2021) doi.org/10.1038/s41586-021-03441-2. See article below for a research brief in layman terms.
Astrocyte cells in the fruit fly brain are an on-off switch that controls when neurons can change and grow
Ackerman SD
The Conversation Science Newsletter, April 12, 2021
Establishment and Maintenance of Neural Circuit Architecture
Heckman EL, Doe CQ (2021)
The Journal of Neuroscience, February 2021, 41(6):1119-1129. doi.org/10.1523/JNEUROSCI.1143-20.2020, PMCID: PMC7888231
The role of astrocyte‐mediated plasticity in neural circuit development and function
Perez-Catalan N, Doe CQ, Ackerman SD (2021)
Neural Development (16-1) 2021, doi: 10.1186/s13064-020-00151-9, PMCID: PMC7789420
Comparative connectomics reveals how partner identity, 1 location, and activity specify synaptic connectivity in Drosophila
Valdes-Aleman J, Fetter RD, Sales EC, Heckman EL, Venkatasubramanian L, Doe CQ, Landgraf M, Cardona A, Zlatic M (2021)
Neuron 109, January 2021, doi: 10.1016/j.neuron.2020. 10.004, PMCID: PMC7837116
Precise levels of nectin-3 are required for proper synapse formation in postnatal visual cortex
Tomorsky J, Parker PR, Doe CQ, Niell CM (2020)
Neural Development (15:13). doi: 10.1186/s13064-020-005-w
A novel temporal identity window generates alternating Eve+/NKx6+ motor neuron subtypes in a single progenitor lineage
Seroka A, Yazejian RM, Lai S-L, Doe CQ. (2020)
Neural Development, (15:9), doi: 10.1186/s13064-020-00146-6, PMCID: PMC7388218
A multilayer circuit architecture for the generation of distinct locomotor behaviors in Drosophila.
Zarin AA, Mark B, Cardona A, Litwin-Kumar A, Doe CQ. (2019)
eLife, December, doi: 10.7554/eLife.51781, PMCID: PMC6994239
Synaptic specificity is collectively determined by partner identity, location and activity.
Valdes-Aleman J, Fetter RD, Sales EC, Doe CQ, Landgraf M, Cardona A, Zlatic M. (2019)
bioRxiv, July, doi: 10.1101/697763
The role of lineage, hemilineage and temporal identity in establishing neuronal connectivity in the Drosophila larval CNS.
Mark B, Lai SL, Zarin AA, Manning L, Cardona A, Truman J, Doe CQ. (2019)
bioRxiv, April, doi: 10.1101/617936
Regulation of subcellular dendritic synapse specificity by axon guidance cues.
Sales EC, Heckman LE, Warren TL, Doe CQ. (2019)
eLife, April, doi: 10.7554/eLife.43478, PMCID: PMC6499537
The Hunchback temporal transcription factor determines motor neuron axon and dendrite targeting in Drosophila.
Seroka AQ, Doe CQ. (2019)
Development 146, March, dev175570. doi:10.1242/dev.175570, PMCID: PMC6467472
Temporal identity establishes columnar neuron morphology, connectivity, and function in a Drosophila navigation circuit.
Sullivan LF, Warren TL, Doe CQ. (2019)
elife, February 2019. PMCID: PMC6386519
Neuroblast-specific chromatin landscapes allows the integration of spatial and temporal cues during Drosophila neurogenesis.
Sen S, Chanchani S, Southall TD, Doe CQ. (2019)
eLife, January. doi.org/10.7554/eLife.44036.001. PMCID: PMC6377230
A repressor-decay timer for robust temporal patterning in embryonic Drosophila neuroblast lineages.
Averbukh I, Lai SL, Doe CQ, Barkai N. (2018)
eLife, December. doi: 10.7554/eLife.38631.001. PMCID: PMC6306102
MDN brain descending neurons coordinately activate backward and inhibit forward locomotion.
Carreira-Rosario A, Zarin AA, Clark MQ, Manning L, Fetter RD, Cardona A, Doe CQ. (2018)
eLife, August, doi.org/10.7554/eLife.38554.001. PMCID: PMC6097840. Movie: Activation of MDN induces backward crawling and walking
Drosophila nucleostemin 3 is required to maintain larval neuroblast proliferation.
Johnson PW, Doe CQ, Lai SL. (2018)
Developmental Biology, August 1;440 (1). 1-12. PMCID: PMC6278609
Neural circuits driving larval locomotion in Drosophila.
Clark MQ, Zarin AA, Carreira-Rosario A, Doe CQ. (2018)
Neural Development, April 19, PMCID: PMC5907184
Drosophila embryonic type II neuroblasts: origin, temporal patterning, and contribution to the adult central complex.
Walsh KT, Doe CQ. (2017)
Development, December 17, 144 (24) PMCID: PMC5769626
TU-Tagging: A Method for Identifying Layer-Enriched Neuronal Genes in Developing Mouse Visual Cortex.
Tomorsky J, DeBlander L, Kentros CG, Doe CQ, Niell CM. (2017)
eNeuro, September/October 4(5) e0181-17. 1-16. PMCID: PMC5659240
Temporal Patterning in the Drosophila CNS.
Doe CQ. (2017)
Annual Review of Cell and Developmental Biology, October 11 33:219-240. https://doi.org/10.1146/annurev-cellbio-111315-125210
Playing Well with Others: Extrinsic Cues Regulate Neural Progenitor Temporal Identity to Generate Neuronal Diversity.
Syed MH, Mark B, Doe CQ. (2017)
Trends in Genetics, September 9, Epub. PMCID: PMC5701851
Opportunities lost and gained: Changes in progenitor competence during nervous system development.
Farnsworth RF, Doe CQ. (2017)
Neurogenesis, July 19, Vol 4, No. 1. PMCID: PMC5479452
Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and flial diversity.
Syed MH, Mark B, Doe CQ. (2017)
eLife, April 10;6 e26287. PMCID: PMC5403213
The Hunchback temporal transcription factor establishes, but is not required to maintain, early-born neuronal identity.
Hirono K, Kohwi M, Clark M, Heckscher E, Doe CQ. (2017)
Neural Development, January 31 12:1. PMCID: PMC5282720
Immunofluorescent antibody staining of intact Drosophila larvae.
Manning L, Doe CQ. (2017)
Nature Protocols, January 12 (1):1-14. PMID: 27906168
Functional Genetic Screen to Identify Interneurons Governing Behaviorally Distinct Aspects of Drosophila Larval Motor Programs.
Clark MQ, McCumsey SJ, Lopez-Darwin S, Heckscher ES, Doe CQ. (2016)
G3: Genes|Genomes|Genetics, Jul 7;6(7):2023-31. PMCID: PMC4938655
Aging Neural Progenitors Lose Competence to Respond to Mitogenic Notch Signaling.
Farnsworth DR, Bayraktar OA, Doe CQ. (2015)
Current Biology, Dec 7;25(23):3058-3068. PMCID: PMC4679507
Even-Skipped(+) Interneurons Are Core Components of a Sensorimotor Circuit that Maintains Left-Right Symmetric Muscle Contraction Amplitude.
Heckscher ES, Zarin AA, Faumont S, Clark MQ, Manning L, Fushiki A, Schneider-Mizel CM, Fetter RD, Truman JW, Zwart MF, Landgraf M, Cardona A, Lockery SR, Doe CQ. (2015)
Neuron, October 21;88(2):314-29. PMCID: PMC4619170
The RanGEF Bj1 Promotes Prospero Nuclear Export and Neuroblast Self-Renewal.
Joy T, Hirono K, Doe CQ. (2015)
Developmental Neurobiology, May;75(5):485-93. PMCID: PMC4397115
Transient nuclear Prospero induces neural progenitor quiescence.
Lai SL, Doe CQ. (2014)
eLIFE, October 29, 3:e03363 PMCID: PMC4212206
Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience.
Heckscher ES, Long F, Layden MJ, Chuang C-H, Manning L, Richart J, Pearson JC, Crews ST, Peng H, Myers E, Doe CQ. (2014)
Development, June; 141(12):2524-2532 PMCID: PMC4050700
Applying thiouracil tagging to mouse transcriptome analysis.
Gay L, Karfilis KV, Miller MR, Doe CQ, Stankunas K. (2014)
Nature Protocols, Feb;9(2):410-20. PMCID: PMC4112099
Temporal fate specification and neural progenitor competence during development.
Kohwi M, Doe CQ. (2013)
Nature Reviews Neuroscience, Dec;14(2):823-38. Review PMCID: PMC3951856
Live Imaging of Neuroblase Lineages within Intact Larval Brains in Drosophila.
Cabernard C, Doe CQ. (2013)
Cold Spring Harbor Protocols, October 1;2013(10). PMID: 24086057
midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila.
Carney TD, Struck AJ, Doe CQ. (2013)
Development, Oct;140(20):4155-64. PMCID: PMC3787755
Formamin-mediated actin polymerization cooperates with Mud/Dynein during Frizzled/Dishevlled spindle orientation.
Johnston CA, Manning L, Lu MS, Golub O, Doe CQ, Prehoda KE. (2013)
Journal of Cell Science, Oct 1;126(jpt 19):4436-44 PMCID: PMC3784822
Combinatorial temporal patterning in progenitors expands neural diversity.
Bayraktar OA, Doe CQ. (2013)
Nature, June 27:498(7455):449-55 PMCID: PMC3941985
Developmentally Regulated Subnuclear Genome Reorganization Restricts Neural Progenitor Competence in Drosophila.
Kohwi M, Lupton JR, Lai S-L, Miller MR, Doe CQ. (2013)
Cell, Jan 17;152(1-2):197-108. PMCID: PMC3670710
Mouse TU tagging: a chemical/genetic intersectional method for purifying cell type-specific nascent RNA.
Gay L, Miller MR, Ventura PB, Devasthali V, Vue Z, Thompson HL, Temple S, Zong H, Cleary MD, Stankunas K, Doe CQ. (2013)
Genes and Development, January 1;27(1):98-115. PMCID: PMC3553287
The snail family member worniu is continuously required in neuroblasts to prevent elav-induced premature differentiation.
Lai S-L, Miller MR, Robinson KJ, Doe CQ. (2012)
Developmental Cell, October 16; 23 (4) 849-57 PMCID: PMC3509944
A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS
Manning L, Heckscher ES, Purice MD, Roberts J, Bennett AL, Kroll JR, Pollard JL, Strader ME, Lupton JR, Dyukareva AV, Doan PN, Bauer DM, Wilbur AN, Tanner S, Kelly JJ, Lai S-L, Tran KD, Kohwi M, Laverty TR, Pearson JC, Crews ST, Rubin GM, Doe CQ. (2012)
Cell Reports, October 21; 2(4):1002-13 PMCID: PMC3523218
Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature.
Heckscher ES, Lockery SR, Doe CQ. (2012)
Journal of Neuroscience, September 5; 32(36:12461-71) PMCID: PMC3711835
Structure of an enzyme-derived phosphoprotein recognition domain.
Johnston CA, Doe CQ, Prehoda KE. (2012)
PLoS One Vol. 7(4) e36014 PMCID: PMC3335814
A conserved haplotype controls parallel adaptation in geographically distant salmonid populations.
Miller MR, Brunelli JP, Wheeler PA, Liu S, Rexroad III CE, Palti, Y., Doe, C.Q., Thorgaard, G.H. (2012)
Molecular Ecology, 21, 237-249. PMCID: PMC3664428
Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts.
Andersen, R.O., Turnbull, D.W., Johnson, E.A., Doe, C.Q. (2012)
Developmental Biology, 363, 258-265. PMCID: PMC4013783
Neurophysiological Defects and Neuronal Gene Deregulation in Drosophila mir-124 Mutants.
Sun, K., Westholm, J.O., Tsurudome, K., Hagen, J.W., Lu, Y., Kohwi, M., Betel, D., Gao, F-B., Haghighi, A.P., Doe, C.Q., Lai, E.C. (2012)
PLos Genetics, V8 (2) e1002515. PMCID: PMC3276548
Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis.
Carney, T.D., Miller, M.R., Robinson, K.J., Bayraktar, O.A., Osterhout, J.A., Doe, C.Q. (2012)
Developmental Biology, 361, 137-146. PMCID: PMC4110207
Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts.
Connell, M., Cabernard, C., Ricketson, D., Doe, C.Q. Prehoda, K.E. (2011)
Molecular Biology of the Cell, V22, 4220-4226. PMCID: PMC3216648
Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing.
Johnston, C.A., Whitney, D.S., Volkman, B.R., Doe, C.Q., Prehoda, K.E. (2011)
PNAS, 108 (44), E973-E978. PMCID: PMC3207680
Canoe binds RanGTP to promote PinsTPR/mud-mediated spindle orientation.
Wee, B., Johnston, C.A., Prehoda, K.E., Doe, C.Q.
The Journal of Cell Biology, 2011, V195 (3), 369-376. PMCID: PMC3206335
Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons.
Hirono, K., Margolis, J.S., Posakony, J.W.. Doe, C.Q.
Gene Expression Patterns, 2011, 12, 11-17. PMCID: PMC3272097|
An Image-Free Opto-Mechanical System for Creating Virtual Environments and Imaging Neuronal Activity in Freely Moving Caenorhabditis elegans.
Faumont, S., Rondeau, G., Thiele, T.R., Lawton. K., McCormick, K.E., Sottile, M., Griesbeck, O., Heckscher, E.S., Roberts, W.M., Doe, C.Q., Lockery, S.R.
PLoS one, 2011, V6(9) e24666 PMCID: PMC3182168
Neuronal Polarity in 2011
Doe, C.Q., Kaibuchi, K.,
Developmental Neurobiology, 2011, 71(6), 401-402. PCMID: PCM21557496
The pipsqueak-domain proteins Distal antenna and DIstal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity.
Kohwi, M., Hiebert, L.S., Doe, C.Q., (2011)
Development 138, 1727-1735. PMCID: PMC3074449
The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish.
Segalen, M., Johnston, C.A., Martin, C.A., Dumortier, J.G., Prehoda, K.E., David, N.B., Doe, C.Q., Bellaiche, Y., (2010)
Developmental Cell 19, 740-752. PMCID: PMC3008569
Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex.
Bayraktar, O.A., Boone, J.Q., Drummond, M.L., Doe, C.Q., (2010)
Neural Development October 1, 5;26 | PMCID: PMC2958855
A spindle-indepedent cleavage furrow positioning pathway.
Cabernard, C., Prehoda, K.E., Doe, C.Q., (2010)
Nature Vol 467, 2 September, 91-95. PMID: 20811457
Fragile X protein controls neural stem cell proliferation in the Drosophila brain.
Callan, MA, Cabrnard C, Heck J, Louis S, Doe CQ, Zarnescu DC., (2010)
Human Molecular Genetics Aug 1;19(15):3068-79. PMCID: PMC2901145
Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity.
Tran, K.D., Miller, M.R., Doe, C.Q., (2010)
Development 137(9), 1421-1430. PMCID: PMC2853844
Previews, Stem Cell Transcriptional Loops Generate Precise Temporal Identity.
Kohwi, M., Doe, C.Q., (2009)
Cell Stem Cell Dec. 4;5(6):577-578. PMID: 19951685
Spindle orientation during asymmetric cell division.
Siller, K.H., Doe, C.Q., (2009)
Nature Cell Biology April V.11(3): 365-374. PMID: 19337318
Allosteric Control of Regulated Scaffolding in Membrane-Associated Guanylate Kinases.
Marcette, J., Hood, I.V., Johnston, C.A., Doe, C.Q., Prehoda, K.E., (2009)
Biochemistry 48, 10014-10019. PMCID: PMC3535437
TU-tagging: cell type-specific RNA isolation from intact complex tissues.
Miller, M.R., Robinson, K.J., Cleary, M.D., Doe, C.Q., (2009)
Nature Methods 6, 439-441. PMCID: PMC2783170
Apical/Basal Spindle Orientation is Required for Neuroblast Homeostasis and Neuronal Differentiation in Drosophila.
Cabernard, C., Doe, C.Q., (2009)
Developmental Cell 17, 134-141. PMID: 19619498
Identification of an Aurora-A/PinsLINKER/Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells.
Johnston, C.A., Hirono, K., Prehoda, K.E., Doe, C.Q. (2009)
Cell 138, 1150-1163. PMCID: PMC2789599
Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal.
Chabu, C, Doe, C.Q., (2009)
Developmental Biology 330, 399-405. PMCID: PMC2728501
Pdm and Castor close successive temporal identity windows in the NB-3 lineage.
Tran, K.D., Doe, C.Q., (2008)
Development 135, 3491-3499. PMCID: PMC3989073
Dap160/intersectin binds and activates aPKC to regulate cell polarity an cell cycle progression.
Chabu, C., Doe, C.Q., (2008)
Development 135, 2739-2746. PMCID: PMC2683763
Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts.
Siller, K.H., Doe, C.Q., (2008)
Developmental Biology 319, 1-9. PMCID: PMC2668259
Identification of Drosophila Type II Neuroblast Lineages Containing Transit Amplifying Ganglion Mother Cells.
Boone, J.Q., Doe, C.Q., (2008)
Developmental Neurobiology 69, 1185-1195. PMCID: PMC2804867
Neural stem cells: balancing self-renewal with differentiation.
Doe, C.Q., (2008)
Development 135, 1575-1587. PMID: 18356248
Drosopila Activin-ß and the Activin-like product Dawdle function redundantly to regulate proliferation in the larvel brain.
Zhu, C.C., Boone, J.Q., Jensen, P.A., Hanna, S., Pdemski, L., Locke, J., Doe, C.Q., O'Connor, M., (2008)
Development 135, 513-521. PMID: 18171686
Tools for neuroanatomy and neurogenetics in Drosophila.
Pfeiffer, B.D., Jennett, A., Hammonds, A.S., Ngo, T.B., Misra, S., Murphy, C., Scully, A., Carlson, J.W., Wan, K.H., Laverty, T.R., Mungall, C., Scirskas, R., Kadonaga, J.T., Doe, C.Q., Eisen, M.B., Celniker, S.E., Rubin, G.M., (2008).
PNAS Vol. 105 (28), 9715-9720. PMCID: PMC2447866
Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6-aPKC.
Atwood, S.X., Chabu, C., Penkert, R.R., Doe, C.Q., Prehoda, K.E., (2007)
Journal of Cell Science 120, 3200-3206. PMCID: PMC1988841
G alpha i generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts.
Nipper, R.W., Siller, K.H., Smith, N.R., Doe, C.Q.. Prehods, K.E., (2007)
PNAS 104 (36), 14306-14311. PMCID: PMC1964812
Stem Cell Self-Renewal: Centrsomes on the Move.
Cabernard, C., Doe, C.Q. (2007)
Current Biology 17: R465-R467. PMID: 17580077
Polarity and intracellular compartmentalization of Drosophila neurons.
Rolls, M.M., Satoh, D., Clyne, P.J., Henner, A.L., Uemura, T., Doe, CQ (2007)
Neural Development Apr 30;2(1):7 PMCID: PMC1868948
Microtubule-induced cortical cell polarity.
Siegrist, S.E., Doe, C.Q. (2007)
Genes & Development Mar 1;21(5):483-96 PMID: 1734411
Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe.
Egger, B.,Boone, J.Q., Stevens, N.R., Brand, A.H., Doe, C.Q. (2007)
Neural Development Jan 5;2:1 PMCID: PMC1779784
Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation.
Lee, C-Y, Andersen, R.O., Cabernard, C., Manning, L., Tran, K.D., Lanskey, M.J., Bashirullah, A., Doe, C.Q. (2006)
Genes & Development 20 (24), 3464-3474, PMCID: PMC1698452
Chinmo and neuroblast temporal identity.
Doe, C.Q. (2006)
Cell Oct 20;127(2):254-6, DOI: 10.1016./j.cell.2006.10.008
Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage.
Grosskortenhaus, R., Robinson, K.J., Doe, C.Q. (2006)
Genes & Development Sep 15;20(18):2618-27, PMCID: PMC1578683
The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts.
Siller, K.H., Cabernard, C., Doe, C.Q. (2006)
Nature Cell Biology Jun;8(6):594-600
Brat Is a Miranda Cargo Protein that Promotes Neuronal Differentiation and Inhibits Neuroblast Self-Renewal
Lee, C-Y., Wilkinson, B.D., Siegrist, S., Wharton, R., Doe, C.Q. (2006)
Developmental Cell 10, 441-449
Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window.
Cleary M., Doe C.Q. (2006)
Genes & Development 20:429-434, PMCID: PMC1369045
Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS.
Layden M.J., Odden J., Schmid A., Garces A., Thor S., Doe CQ, (2006)
Developmental Biology 291:253-263
Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts.
Siegrist, S.E., Doe, C.Q. (2006)
Development Feb 133(3):529-36, PMID: 16396904
Microtubule-Induced Pins/Gai Cortical Polarity in Drosophila Neuroblasts.
Siegrist S., Doe C.Q. (2005)
Cell Dec 29;123(7):1323-1335, PMID: 16377571
Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for Lis1/Dynactin in Spindle Assembly and Mitotic Checkpoint Control.
Siller K., Serr M., Steward R., Hays T.S., Doe C.Q. (2005)
Molecular Biology of the Cell 16;5127-5140,PMCID: PMC1266413
Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila.
Armstrong, J.A., Sperling, A.S., Deuring, R., Manning, L., Moseley, S.L., Papoulas, O., Piatek, C.I., Doe, C.Q., Tamkun, J.W. (2005)
Genetics Aug 170(4):1761-74
Regulation of temporal identity transitions in Drosophila neuroblasts.
Grosskortenhaus R, Pearson BJ, Marusich A, Doe C.Q. (2005)
Developmental Cell. 2005 Feb;8(2):193-202
Karcavich, R. and Doe, C.Q. (2005) The Journal of Comparative Neurology, 481:240-251
The Drosophila neuroblast 7-3 cell lineage: a model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of GMC identity.
Lee C-Y., Robinson K., Doe C.Q. (2005) Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation.
Nature 439(2) 594-598
Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation.
Cheesman, S., Layden, M., von Ohlen, T., Doe, C.Q. and Eisen, J.S. (2004)
Development 131 5221-5232.
Specification of temporal identity in the developing nervous system.
Pearson, B., Doe, C.Q. (2004)
Annual Review of Cell and Developmental Biology, Vol. 20, pages 619-647.
Par-6 and aPKC are polarized in mature neurons, but are not required for in vivo axon specification in Drosophila.
Rolls, M.M., Doe, C.Q. Baz, (2004)
Nature Neuroscience, Dec: 7(12), 1293-5. PMID: 15543144
Abstrakt, a DEAD box protein, regulates inscuteable at a post-transcriptional level and is required for asymmetric division of neural and mesodermal progenitors.
Irion, U., Leptin, M., Siller, K., Fuerstenberg, S., Cai, Y., Doe, C.Q., Chia, W., and Yang, X. (2004)
Current Biology, 14, 138-144.
Maintaining Youth in Drosophila Neural Progenitors.
Isshiki, T. and Doe, C.Q. (2004)
Cell Cycle, Volume 3, Issue 3, 296-299, PMID: 14726657
Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity.
Albertson, R., Chabu, C., Sheehan, A. and Doe, C.Q. (2003)
Journal of Cell Science 117, 6061-6070
Regulation of neuroblast competence in Drosophila.
Pearson, B. and Doe, C.Q. (2003)
Nature, 425, 624-628
Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function.
Freeman, M., Delrow, J., Kim, J., Johnson, E., Doe, C.Q. (2003)
Neuron, 38, 567-580
Specification of motoneuron fate in Drosophila: Integration of positive and negative transcription factor inputs by a minimal eve enhancer.
McDonald, J.A. Fujioka, M., Odden, J.P., Jaynes, J.B., Doe, C.Q. (2003)
Journal of Neurobiology 57(2), 193-203
Cell Polarity: From embryo to axon.
Rolls, M.M. and Doe, C.Q. (2003)
Nature, 421, 905-906 (27 February 2003) PMID: 12606985
Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry.
Albertson, R. and Doe, C.Q. (2003)
Nature Cell Biology Feb:5(2): 166-70, PMID: 12545176
Structure of the DNA-binding Region of Prospero Reveals a Novel Homeo-prospero Domain.
Ryter JM, Doe CQ, and Matthews BW (2002)
Structure 10, 1541-1549.
Drosophila HB9 is expressed in a subset of motoneurons and interneurons where it regulates gene expression and axon pathfinding.
Odden J, Holbrook S, and Doe CQ (2002)
J. Neurosci. 22, 9143-9149. doi.org/10.1523/JNEUROSCI.22-21-09143.2002
Drosophila neuroblasts sequentially express transcription factors which specify the temporal identity of their neuronal progeny.
Isshiki T, Pearson B, Holbrook S, and Doe CQ (2001)
Cell, 106, 511-521
Asymmetric Prospero localization is required to generate mixed neuronal/glial lineages in the Drosophila CNS.
Freeman MR and Doe CQ (2001)
Development, 128, 4103-4112.
Drosophila Amphiphysin is implicated in protein localization and membrane morphogenesis but not in endocytosis.
Zelhof AC, Bao H, Hardy RW, Razzaq A, Zhang B, and Doe CQ (2001)
Development, 128, 5005-5015.
Asymmetric cell division: fly neuroblast meets worm zygote.
Doe CQ and Bowerman BB (2001)
Current Opinion Cell Biology, 13, 68-75.
Cell polarity: the PARty expands.
Doe CQ (2001)
Nature Cell Biology, 3, E1-E3.