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Chris Q. Doe, Ph.D.

Principal Investigator

Professor & Co-Chair

Institute of Neuroscience

Investigator, Howard Hughes Medical Institute

 

 

B.S., New College

Ph.D. Stanford University

 

cdoe@uoregon.edu

RESEARCH INTERESTS

 

 Chris Doe investigates central nervous system (CNS) development. His lab is currently interested in (1) asymmetric cell division and self-renewal/differentiation of Drosophila neural stem cells, (2) temporal identity programs used to generate an ordered series of neural progeny from a single progenitor, (3) the generation of interneuron diversity and establishment of neural circuits that drive larval locomotion, and (4) the use of TU tagging—a method for covalently labeling nascent RNA in specific cell types within intact tissues—to identify temporally regulated or activity-regulated RNAs in the mouse CNS.

 

Sen-Lin Lai, Ph.D.

Research Specialist

 

B.S. National Tsing Hua Univ., Taiwan

M.S. National Tsing Hua Univ., Taiwan

Ph.D. UMass Medical School

 

slai@uoneuro.uoregon.edu

RESEARCH INTERESTS

 

Mutations such as prospero lead to brain tumors due to the transformation of neurons back to neural stem cells. Notably, other mutations have the opposite effect of eliminating neural stem cells (producing fruit flies with extremely small brains).

 

Aref Arzan Zarin

PostDoc

 

B.Sc. Kharazmi Univ., Tehran, Iran

M.Sc. Tarbiat Modaress Univ (TMU) Iran

Ph.D. Trinity College Dublin, Ireland

         Labrador JP lab

 

arefa@uoregon.edu

RESEARCH INTERESTS

 

Rhythmic behaviors are set of cyclic movements involved in vital physiological processes (e.g. locomotion, respiration, mastication, etc) of all animals. How these behaviors are performed is still a big challenge for neuroscientists. Among rhythmic behaviors, locomotion presents an experimentally amenable model system for studying how ensembles of neurons conduct a specific behavioral output.  We study peristaltic larval locomotion of Drosophila as a model of rhythmic behavior.

 

 

Sarah Ackerman

PostDoc

 

B.S. The College of New Jersey, Ewing

 

Ph.D. Washington University School

         of Medicine

 

 

sarah.d.ackerman@gmail.com

RESEARCH INTERESTS

 

The mammalian brain is formed by billions of neurons which communicate at specialized chemical junctions called synapses. Individual neurons connect to form functional circuits, which are required for proper learning and memory. I'm interested in understanding the process by which a given neuron finds the correct synaptic pair, and how these synapses are maintained and modified over time. Recent works have identified astrocytes, the most abundant CNS glial cell type, as a major regulator of synaptic development. Using the Drosophila larval system, my work will test the hypothesis that astrocytes inform circuit formation and function.

Tim Warren

PostDoc

 

A.B Physics, Harvard University

 

Ph.D. Neuroscience, University of

California, San Francisco

 

 

timlwarren@gmail.com

RESEARCH INTERESTS

 

 

I am studying the neural mechanisms that underlie spatial navigation in Drosophila. I am particularly interested in understanding how the central complex, a midline region conserved across all insects, supports flies' capacity to maintain a straight heading over long flights.

Luis Sullivan

Grad Student

 

 

B.S. George Mason University

 

 

lsulliv9@gmail.com

RESEARCH INTERESTS

 

The patterning of progenitors into post-mitotic neurons provides the essential logic to generate appropriate neurons in correct locations at correct stages in development, but it is unknown if progenitors also specify the physiological properties of their adult progeny.  Previous research has uncovered highly conserved transcription factors that are sequentially expressed in neural progenitors, where they act to generate a diverse range of neural progeny.  These sequential arrays of transcription factors specify cell fate, I aim to determine if they also specify the “columnar-identity” of a neuron in the adult central complex of Drosophila.

Emily Sales

Grad Student

 

B.S. Neuroscience, University of California, Santa Cruz

 

 

esales@uoregon.edu

RESEARCH INTERESTS

 

I am interested in the role of cell surface molecules in the development of neural circuits.   Using genetic tools in the larval ventral nerve cord, I can visualize individual neurons and test the function of cell surface molecules in the assembly of neural circuits.

Brandon Mark

Grad Student

 

B.S. Pennsylvania State University

 

 

bmark@uoregon.edu

RESEARCH INTERESTS

 

How does a neuron know which connections to make?  While much is known about different aspects that contribute to synaptic specificity such as axon guidance and adhesion molecules, the developmental determinants of these mechanisms remains relatively unknown.  I am interested in how temporal and spatial patterning mechanisms that convey neuronal identity contribute to the specification of connectivity.

Emily Heckman

Grad Student

 

B.S. Lehigh University

 

 

 

 

eheckman@uoregon.edu

RESEARCH INTERESTS

 

The continuous function of the human nervous system is dependent upon the maintenance of trillions of synaptic connections. My goal is to identify the molecular mechanisms that are required for the maintenance and restoration of synapses in the CNS, using the fruit fly as a model. My central hypothesis is that cell adhesion molecules, implicated in the establishment of synapses, are also required for their long-term maintenance.

Austin Seroka

Grad Student

 

B.S. New College

 

 

 

 

aseroka@uoregon.edu

RESEARCH INTERESTS

 

During nervous system development, each individual neuron is tasked with locating the correct synaptic partners and establishing synaptic connectivity. I am interested in the developmental mechanisms underlying the assembly of motor circuits in the Drosophila VNC, including the specification of neuronal connectivity by temporal patterning and birth order. I address these questions using stochastic cell labelling, live imaging and optogenetic tools.

Laurina Manning

Research Specialist

 

 

B.S. Colorado State University

M.Ed. University of Oregon

 

 

rina@uoregon.edu

Keiko Hirono

Research Specialist

 

 

BPharm. Kyoritsu College of Pharmacy

Master of Pharmaceutical Sciences

Kyoritsu College of Pharmacy

 

 

keiko@uoneuro.uoregon.edu

Janet Hanawalt

Administrative Assistant

 

 

B.S. University of Oregon

 

 

 

janeth@uoregon.edu

Zia

PhD Dogtorate

 

Research in Squeaky toy

dissection and napping

 

Current Undergrads

 

Kim Corona

   kcorona@uoregon.edu

 

Nelson Perez Catalan

   nelsonp@uoregon.edu

 

Amanda Linskens

   alinske2@uoregon.edu

 

 

Rita Yazejian

   ritay@uoregon.edu

 

 

Sonja Zolnoski

   sonjaz@uoregon.edu

© 2018 Doe Lab