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Walter and Mullins Sneech manifesto 2016 ASCB Newsletter

Volume 39, Number 8 November/December 2016. ISSN 1060-8982


Lai SL, Doe CQ. (2014) Transient nuclear Prospero induces neural progenitor quiescence. eLIFE October 29, 3:e03363 PMCID: PMC4212206


Heckscher ES, Long F, Layden MJ, Chuang C-H, Manning L, Richart J, Pearson JC, Crews ST, Peng H, Myers E, Doe CQ. (2014) Atlas-builder software and the eNeuro atlas: resources for developmental biology and neuroscience.  Development.  June; 141(12):2524-2532 PMCID: PMC4050700


Gay L, Karfilis KV, Miller MR, Doe CQ, Stankunas K. (2014) Applying thiouracil tagging to mouse transcriptome analysis. Nature Protocols. Feb;9(2):410-20. PMCID: PMC4112099

Kohwi M, Doe CQ. (2013) Temporal fate specification and neural progenitor competence during development. Nature Reviews Neuroscience. Dec;14(2):823-38. Review PMCID: PMC3951856


Cabernard C, Doe CQ. (2013) Live Imaging of Neuroblase Lineages within Intact Larval Brains in Drosophila. Cold Spring Harbor Protocols. October 1;2013(10). PMID: 24086057


Carney TD, Struck AJ, Doe CQ. (2013) midlife crisis encodes a conserved zinc-finger protein required to maintain neuronal differentiation in Drosophila. Development. Oct;140(20):4155-64. PMCID: PMC3787755


Johnston CA, Manning L, Lu MS, Golub O, Doe CQ, Prehoda KE. (2013) Formamin-mediated actin polymerization cooperates with Mud/Dynein during Frizzled/Dishevlled spindle orientation. Journal of Cell Science. Oct 1;126(jpt 19):4436-44

PMCID: PMC3784822


Bayraktar OA, Doe CQ. (2013) Combinatorial temporal patterning in progenitors expands neural diversity. Nature. June 27:498(7455):449-55 PMCID: PMC3941985


Kohwi M, Lupton JR, Lai S-L, Miller MR, Doe CQ. (2013) Developmentally Regulated Subnuclear Genome Reorganization Restricts Neural Progenitor Competence in Drosophila. Cell. Jan 17;152(1-2):197-108. PMCID: PMC3670710


Gay L, Miller MR, Ventura PB, Devasthali V, Vue Z, Thompson HL, Temple S, Zong H, Cleary MD, Stankunas K, Doe CQ. (2013)  Mouse TU tagging: a chemical/genetic intersectional method for purifying cell type-specific nascent RNA. Genes and Development. January 1;27(1):98-115.  PMCID: PMC3553287

Lai S-L, Miller MR, Robinson KJ, Doe CQ. (2012) The snail family member worniu is continuously required in neuroblasts to prevent elav-induced premature differentiation. Developmental Cell, October 16; 23 (4) 849-57  PMCID: PMC3509944

Manning L, Heckscher ES, Purice MD, Roberts J, Bennett AL, Kroll JR, Pollard JL, Strader ME, Lupton JR, Dyukareva AV, Doan PN, Bauer DM, Wilbur AN, Tanner S, Kelly JJ, Lai S-L, Tran KD, Kohwi M, Laverty TR, Pearson JC, Crews ST, Rubin GM, Doe CQ. (2012) A Resource for Manipulating Gene Expression and Analyzing cis-Regulatory Modules in the Drosophila CNS. Cell Reports October 21; 2(4):1002-13  PMCID: PMC3523218

Heckscher ES, Lockery SR, Doe CQ. (2012) Characterization of Drosophila larval crawling at the level of organism, segment, and somatic body wall musculature. Journal of Neuroscience September 5; 32(36:12461-71)

PMCID: PMC3711835

Johnston CA, Doe CQ, Prehoda KE. (2012) Structure of an enzyme-derived phosphoprotein recognition domain. PLoS One Vol. 7(4) e36014  PMCID: PMC3335814

Miller MR, Brunelli JP, Wheeler PA, Liu S, Rexroad III CE, Palti, Y., Doe, C.Q. (2012) Thorgaard, G.H. A conserved haplotype controls parallel adaptation in geographically distant salmonid populations. Molecular Ecology 21, 237-249. PMCID: PMC3664428

Andersen, R.O., Turnbull, D.W., Johnson, E.A., Doe, C.Q., (2012) Sgt1 acts via an LKB1/AMPK pathway to establish cortical polarity in larval neuroblasts. Developmental Biology 363, 258-265. PMCID: PMC4013783

Sun, K., Westholm, J.O., Tsurudome, K., Hagen, J.W., Lu, Y., Kohwi, M., Betel, D., Gao, F-B., Haghighi, A.P., Doe, C.Q., Lai, E.C. (2012) Neurophysiological Defects and Neuronal Gene Deregulation inDrosophila mir-124 Mutants. PLos Genetics V8 (2) e1002515. PMCID: PMC3276548

Carney, T.D., Miller, M.R., Robinson, K.J., Bayraktar, O.A., Osterhout, J.A., Doe, C.Q. (2012) Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis. Developmental Biology 361, 137-146. PMCID: PMC4110207

Connell, M., Cabernard, C., Ricketson, D., Doe, C.Q. Prehoda, K.E. (2011) Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts. Molecular Biology of the Cell V22, 4220-4226. PMCID: PMC3216648

Johnston, C.A., Whitney, D.S., Volkman, B.R., Doe, C.Q., Prehoda, K.E. (2011) Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing. PNAS 108 (44), E973-E978. PMCID: PMC3207680

Wee, B., Johnston, C.A., Prehoda, K.E., Doe, C.Q. (2011) Canoe binds RanGTP to promote PinsTPR/mud-mediated spindle orientation. The Journal of Cell Biology V195 (3), 369-376. PMCID: PMC3206335

Hirono, K., Margolis, J.S., Posakony, J.W.. Doe, C.Q. (2011) Identification of hunchback cis-regulatory DNA conferring temporal expression in neuroblasts and neurons. Gene Expression Patterns 12, 11-17. PMCID: PMC3272097|

Faumont, S., Rondeau, G., Thiele, T.R., Lawton. K., McCormick, K.E., Sottile, M., Griesbeck, O., Heckscher, E.S., Roberts, W.M., Doe, C.Q., Lockery, S.R. (2011) An Image-Free Opto-Mechanical System for Creating Virtual Environments and Imaging Neuronal Activity in Freely Moving Caenorhabditis elegans. PLoS one V6(9) e24666 PMCID: PMC3182168

Doe, C.Q., Kaibuchi, K., (2011) Neuronal Polarity in 2011. Developmental Neurobiology 71(6), 401-402.

PCMID: PCM21557496

Kohwi, M., Hiebert, L.S., Doe, C.Q., (2011) The pipsqueak-domain proteins Distal antenna and DIstal antenna-related restrict Hunchback neuroblast expression and early-born neuronal identity. Development 138, 1727-1735. PMCID: PMC3074449

Segalen, M., Johnston, C.A., Martin, C.A., Dumortier, J.G., Prehoda, K.E., David, N.B., Doe, C.Q., Bellaiche, Y., (2010) The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish. Developmental Cell 19, 740-752.  PMCID: PMC3008569

Bayraktar, O.A., Boone, J.Q., Drummond, M.L., Doe, C.Q., (2010) Drosophila type II neuroblast lineages keep Prospero levels low to generate large clones that contribute to the adult brain central complex. Neural Development October 1, 5;26 |  PMCID: PMC2958855

Cabernard, C., Prehoda, K.E., Doe, C.Q., (2010) A spindle-indepedent cleavage furrow positioning pathway. Nature Vol 467, 2 September, 91-95. PMID: 20811457

Callan, MA, Cabrnard C, Heck J, Louis S, Doe CQ, Zarnescu DC., (2010) Fragile X protein controls neural stem cell proliferation in the Drosophila brain. Human Molecular Genetics Aug 1;19(15):3068-79. PMCID: PMC2901145

Tran, K.D., Miller, M.R., Doe, C.Q., (2010) Recombineering Hunchback identifies two conserved domains required to maintain neuroblast competence and specify early-born neuronal identity. Development 137(9), 1421-1430. PMCID: PMC2853844

Kohwi, M., Doe, C.Q., (2009) Previews, Stem Cell Transcriptional Loops Generate Precise Temporal Identity. Cell Stem Cell Dec. 4;5(6):577-578. PMID: 19951685

Siller, K.H., Doe, C.Q., (2009) Spindle orientation during asymmetric cell division. Nature Cell Biology April V.11(3): 365-374.  PMID: 19337318

Marcette, J., Hood, I.V., Johnston, C.A., Doe, C.Q., Prehoda, K.E., (2009) Allosteric Control of Regulated Scaffolding in Membrane-Associated Guanylate Kinases. Biochemistry 48, 10014-10019. PMCID: PMC3535437

Miller, M.R., Robinson, K.J., Cleary, M.D., Doe, C.Q., (2009) TU-tagging: cell type-specific RNA isolation from intact complex tissues. Nature Methods 6, 439-441.  PMCID: PMC2783170

Cabernard, C., Doe, C.Q., (2009) Apical/Basal Spindle Orientation is Required for Neuroblast Homeostasis and Neuronal Differentiation in Drosophila. Developmental Cell 17, 134-141. PMID: 19619498

Johnston, C.A., Hirono, K., Prehoda, K.E., Doe, C.Q. (2009) Identification of an Aurora-A/PinsLINKER/Dlg Spindle Orientation Pathway using Induced Cell Polarity in S2 Cells. Cell 138, 1150-1163.  PMCID: PMC2789599

Chabu, C, Doe, C.Q., (2009) Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal. Developmental Biology 330, 399-405.  PMCID: PMC2728501

Tran, K.D., Doe, C.Q., (2008) Pdm and Castor close successive temporal identity windows in the NB-3 lineage. Development 135, 3491-3499. PMID: 18832394

Chabu, C., Doe, C.Q., (2008) Dap160/intersectin binds and activates aPKC to regulate cell polarity an cell cycle progression. Development 135, 2739-2746.  PMCID: PMC2683763

Siller, K.H., Doe, C.Q., (2008) Lis1/dynactin regulates metaphase spindle orientation in Drosophila neuroblasts. Developmental Biology 319, 1-9. PMCID: PMC2668259

Boone, J.Q., Doe, C.Q., (2008) Identification of Drosophila Type II Neuroblast Lineages Containing Transit Amplifying Ganglion Mother Cells. Developmental Neurobiology 69, 1185-1195.  PMCID: PMC2804867

Doe, C.Q., (2008) Neural stem cells: balancing self-renewal with differentiation. Development 135, 1575-1587.               PMID: 18356248


Zhu, C.C., Boone, J.Q., Jensen, P.A., Hanna, S., Pdemski, L., Locke, J., Doe, C.Q., O'Connor, M., (2008) Drosopila Activin-ß and the Activin-like product Dawdle function redundantly to regulate proliferation in the larvel brain. Development 135, 513-521. PMID: 18171686

Pfeiffer, B.D., Jennett, A., Hammonds, A.S., Ngo, T.B., Misra, S., Murphy, C., Scully, A., Carlson, J.W., Wan, K.H., Laverty, T.R., Mungall, C., Scirskas, R., Kadonaga, J.T., Doe, C.Q., Eisen, M.B., Celniker, S.E., Rubin, G.M., (2008). Tools for neuroanatomy and neurogenetics in Drosophila. PNAS Vol. 105 (28), 9715-9720. PMCID: PMC2447866

Atwood, S.X., Chabu, C., Penkert, R.R., Doe, C.Q., Prehoda, K.E., (2007) Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6-aPKC. Journal of Cell Science 120, 3200-3206. PMCID: PMC1988841

Nipper, R.W., Siller, K.H., Smith, N.R., Doe, C.Q.. Prehods, K.E., (2007) G alpha i generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts. PNAS 104 (36), 14306-14311.  PMCID: PMC1964812

Cabernard, C., Doe, C.Q. (2007) Stem Cell Self-Renewal: Centrsomes on the Move. Current Biology 17: R465-R467.      PMID: 17580077


Rolls, M.M., Satoh, D., Clyne, P.J., Henner, A.L., Uemura, T., Doe, CQ (2007) Polarity and intracellular compartmentalization of Drosophila neurons. Neural Development Apr 30;2(1):7  PMCID: PMC1868948

Siegrist, S.E., Doe, C.Q. (2007) Microtubule-induced cortical cell polarity. Genes & Development Mar 1;21(5):483-96         PMID: 1734411


Egger, B.,Boone, J.Q., Stevens, N.R., Brand, A.H., Doe, C.Q. (2007) Regulation of spindle orientation and neural stem cell fate in the Drosophila optic lobe. Neural Development Jan 5;2:1  PMCID: PMC1779784


Lee, C-Y, Andersen, R.O., Cabernard, C., Manning, L., Tran, K.D., Lanskey, M.J., Bashirullah, A., Doe, C.Q. (2006) Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes & Development 20 (24), 3464-3474

Doe, C.Q. (2006) Chinmo and neuroblast temporal identity. Cell Oct 20;127(2):254-6

Grosskortenhaus, R., Robinson, K.J., Doe, C.Q. (2006) Pdm and Castor specify late-born motor neuron identity in the NB7-1 lineage. Genes & Development Sep 15;20(18):2618-27

Siller, K.H., Cabernard, C., Doe, C.Q. (2006) The NuMA-related Mud protein binds Pins and regulates spindle orientation in Drosophila neuroblasts. Nature Cell Biology Jun;8(6):594-600

Lee, C-Y., Wilkinson, B.D., Siegrist, S., Wharton, R., Doe, C.Q. (2006) Brat Is a Miranda Cargo Protein that Promotes Neuronal Differentiation and Inhibits Neuroblast Self-Renewal. Developmental Cell 10, 441-449

Cleary M., Doe C.Q. (2006) Regulation of neuroblast competence: multiple temporal identity factors specify distinct neuronal fates within a single early competence window. Genes & Development 20:429-434

Layden M.J., Odden J., Schmid A., Garces A., Thor S., Doe CQ, (2006) Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS. Developmental Biology 291:253-263

Siegrist, S.E., Doe, C.Q. (2006) Extrinsic cues orient the cell division axis in Drosophila embryonic neuroblasts. Development Feb 133(3):529-36, PMID: 16396904

Siegrist S., Doe C.Q. (2005) Microtubule-Induced Pins/Gai Cortical Polarity in Drosophila Neuroblasts. Cell  Dec 29;123(7):1323-1335, PMID: 16377571


Siller K., Serr M., Steward R., Hays T.S., Doe C.Q. (2005) Live Imaging of Drosophila Brain Neuroblasts Reveals a Role for Lis1/Dynactin in Spindle Assembly and Mitotic Checkpoint Control. Molecular Biology of the Cell 16;5127-5140

Armstrong, J.A., Sperling, A.S., Deuring, R., Manning, L., Moseley, S.L., Papoulas, O., Piatek, C.I., Doe, C.Q., Tamkun, J.W. (2005) Genetic screens for enhancers of brahma reveal functional interactions between the BRM chromatin-remodeling complex and the delta-notch signal transduction pathway in Drosophila. Genetics Aug 170(4):1761-74

Grosskortenhaus R, Pearson BJ, Marusich A, Doe C.Q. (2005) Regulation of temporal identity transitions in Drosophila neuroblasts. Developmental Cell. 2005 Feb;8(2):193-202

Karcavich, R. and Doe, C.Q. (2005) The Drosophila neuroblast 7-3 cell lineage: a model system for studying programmed cell death, Notch/Numb signaling, and sequential specification of GMC identity. The Journal of Comparative Neurology, 481:240-251

Lee C-Y., Robinson K., Doe C.Q. (2005) Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 439(2) 594-598

Cheesman, S., Layden, M., von Ohlen, T., Doe, C.Q. and Eisen, J.S. (2004) Zebrafish and fly Nkx6 proteins have similar CNS expression patterns and regulate motoneuron formation. Development 131 5221-5232.

Pearson, B., Doe, C.Q. (2004) Specification of temporal identity in the developing nervous system. Annual Review of Cell and Developmental Biology, Vol. 20, pages 619-647.

Rolls, M.M.,  Doe, C.Q. Baz, (2004) Par-6 and aPKC are polarized in mature neurons, but are not required for in vivo axon specification in Drosophila. Nature Neuroscience, Dec: 7(12), 1293-5. PMID: 15543144

Irion, U., Leptin, M., Siller, K., Fuerstenberg, S., Cai, Y., Doe, C.Q., Chia, W., and Yang, X. (2004) Abstrakt, a DEAD box protein, regulates inscuteable at a post-transcriptional level and is required for asymmetric division of neural and mesodermal progenitors. Current Biology, 14, 138-144.

Isshiki, T. and Doe, C.Q. (2004) Maintaining Youth in Drosophila Neural Progenitors. Cell Cycle, Volume 3, Issue 3, 296-299, PMID: 14726657

Albertson, R., Chabu, C., Sheehan, A. and Doe, C.Q. (2003) Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity. Journal of Cell Science 117, 6061-6070

Pearson, B. and Doe, C.Q. (2003) Regulation of neuroblast competence in Drosophila. Nature, 425, 624-628

Freeman, M., Delrow, J., Kim, J., Johnson, E., Doe, C.Q. (2003) Unwrapping glial biology: Gcm target genes regulating glial development, diversification, and function. Neuron, 38, 567-580

McDonald, J.A. Fujioka, M., Odden, J.P., Jaynes, J.B., Doe, C.Q. (2003) Specification of motoneuron fate in Drosophila: Integration of positive and negative transcription factor inputs by a minimal eve enhancer. Journal of Neurobiology 57(2), 193-203

Rolls, M.M. and Doe, C.Q. (2003) Cell Polarity: From embryo to axon. Nature, 421, 905-906 (27 February 2003) PMID: 12606985

Albertson, R. and Doe, C.Q. (2003) Dlg, Scrib and Lgl regulate neuroblast cell size and mitotic spindle asymmetry. Nature Cell Biology Feb:5(2): 166-70, PMID: 12545176

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